Isaac is best known for his roles in A Most Violent Year (2014), Ex Machina (2015), X-Men: Apocalypse (2016). Star Wars sequel trilogy (2015–2019), Annihilation (2018), Dune (2021), and The Card Counter (2021). Isaac has starred in the HBO miniseries Show Me a Hero (2015) and Scenes from a Marriage (2021).
Isaac previously told about adjusting the way he played Moon Knight and his dual characters Marc Spector and Steven Grant midway through shooting. he admits that he initially asked to film all of Marc’s material separately from Steven’s, only to become more confident jumping between the two alters later on. “As I got more comfortable and I really got a handle on both characters, it became easier to switch in-between the two, even in the same moment,” Isaac recalled.